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In yet another embodiment, R 7 is a pyridylalkynyl group? In one embodiment, the method comprises introducing into an organism a target gene of interest which is under the control of at least one tet operator and an expressible nucleotide sequence encoding a revTetR, and contacting the organism with a concentration of tetracycline or tetracycline analog sufficient to alter the level of transcription of the target gene.

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